Ole Gunnar Solskjaer's team registered a 1-0 win in Belgrade a fortnight ago and are one of just two clubs yet to concede a goal in the competition.
The Norwegian urged his United players to bounce back from Saturday's 1-0 loss at Bournemouth that left them a dismal 10th in the table.
"You have got to react, you have got to recover," said Solskjaer, who is still without Paul Pogba because of an ankle problem.
"We have two more games before the international break, we've got a chance on Thursday to qualify in Europe and then Brighton at home - so we need a response" .